Microplastics as an environmental factor exacerbate cholestatic liver injury: Multi-omics evidence from human bile and murine models reveals a synergistic disruption of bile acid homeostasis and endoplasmic reticulum stress

Microplastics, nanoplastics and liver disease: an emerging health concern?

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Researchers reviewed emerging evidence that microplastics and nanoplastics accumulate in human liver tissue at increasing concentrations over the past decade, trigger oxidative stress, fibrogenesis, and inflammation in cell and animal models, and may carry microbial pathogens and endocrine-disrupting chemicals, introducing the concept of plastic-induced liver injury as a new focus for environmental hepatology.

20260228 Dietary microplastic impair liver regeneration

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This research reviewed clinical evidence on the health impacts of microplastic exposure in humans, synthesizing findings from biomonitoring studies, epidemiological investigations, and in vitro toxicology. The review identifies associations between microplastic body burden and inflammatory outcomes, while noting significant gaps in long-term exposure studies.

20260228 Dietary microplastic impair liver regeneration

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This study examined the impacts of plastic pollution on marine life in Palawan, Philippines, documenting plastic ingestion and entanglement in local fish, sea turtles, or other marine species. The findings highlight the ecological toll of inadequate waste management in a globally recognized biodiversity hotspot.

A SWATH-MS Based Analytical Workflow for Combined Proteomic and Metabolomic Profiling of Microplastics-Induced Hepatic Molecular Alterations

Disruption of lipid metabolism under plastic siege: Unraveling the toxic mechanisms of microplastics and nanoplastics

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Researchers reviewed how microplastics and nanoplastics disrupt lipid metabolism across multiple animal species, finding they inhibit digestive enzymes, alter gut microbiota, dysregulate fat storage and breakdown, and activate inflammatory signaling pathways — causing both acute and chronic metabolic damage.