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Network Toxicology and Multi-omics Analysis
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This entry contains data and code supporting a study that used computational methods to investigate how microplastics may worsen diabetic kidney disease at the molecular level. The parent study suggests microplastics could affect kidney health through specific biological pathways, though this entry itself is a data repository rather than a full paper.
The original data code for the article "Revealing the Molecular Toxicity of Microplastics in Diabetic Nephropathy: Integrated Insights from Network Toxicology and Multi-omics Analysis."
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Network Toxicology and Multi-omics Analysis
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This is a duplicate entry for data and code supporting a computational study on how microplastics may contribute to diabetic kidney disease. The parent study used network analysis and molecular modeling to identify potential biological mechanisms linking microplastic exposure to kidney damage.
Network toxicology and bioinformatics analysis reveal the molecular mechanisms of polyethylene terephthalate microplastics in exacerbating diabetic nephropathy
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This computational study used bioinformatics to explore how polyethylene terephthalate (PET) microplastics might worsen diabetic kidney disease. The analysis identified key genes and inflammatory pathways that are affected by both PET microplastics and kidney damage in diabetes. The findings suggest that microplastic exposure could accelerate kidney problems in people who already have diabetes, though lab and clinical studies are needed to confirm this.
Toxicological Effects of Polyethylene Terephthalate Microplastics on Chronic Kidney Disease: An Integrative Bioinformatics, Network Toxicology, and Machine Learning Study.
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This study used computer-based methods, including gene databases and molecular docking, to examine how PET plastic particles might affect chronic kidney disease. The analysis identified seven genes that both PET microplastics and kidney disease may affect, often related to immune, inflammation, and energy processes. No animals or human volunteers were tested directly.
Unveiling the molecular toxicity of plasticizers derived from microplastics (DMP and DEP) in diabetic kidney disease: integrative insights from network toxicology and multi-omics analysis
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Scientists found that two chemicals commonly released from microplastics (used to make plastics flexible) can damage kidney cells in lab tests, and this damage got worse when combined with high blood sugar levels similar to those seen in diabetes. This early-stage research points to specific genes that may explain how these plastic chemicals harm kidney health, but the findings come from cell studies, not humans, so more research is needed before we know if this applies to real-world diabetic kidney disease. Still, it raises important questions about whether everyday plastic exposure could compound health risks for people with diabetes.
Multi-omics and genetic prioritization identify candidate molecular links between micro- and nanoplastics-associated signatures and chronic kidney disease
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Scientists used advanced computer modeling and lab tests to explore how tiny plastic particles (microplastics) found in our bodies might contribute to chronic kidney disease. They identified specific genes and biological pathways linking plastic exposure to kidney damage, and confirmed in lab-grown kidney cells that polystyrene microplastics can trigger changes linked to kidney scarring. While this is early-stage research that doesn't prove plastics directly cause kidney disease in people, it offers promising leads for understanding—and potentially preventing—environmentally-driven kidney damage.
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