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Article
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Tier 2
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Original research — experimental, observational, or case-control study. Direct primary evidence.
Human Health Effects
Marine & Wildlife
Nanoplastics
Reproductive & Development
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Disruption of light–dark rhythms alters embryonic development toxicity and neurotoxicity of nanoplastics on zebrafish larvae by regulating thyroid pathways
Environmental Science Nano
2025
Bingchuan Nie,
Jing Wang,
Weixuan Hu,
Jiaoyue Cong,
Yanjun Fang,
Lei Wang,
Zhenghua Duan
Summary
Researchers found that disruption of light-dark cycles alters the developmental toxicity and neurotoxicity of nanoplastics in zebrafish larvae, with continuous light or dark exposure modifying thyroid pathways and producing different behavioral outcomes than standard light conditions.
Continuous light and dark exposure enhance developmental toxicity of NPs on zebrafish larvae, but decrease larval swimming distances caused by NPs, which is opposite to the effect under NP single exposure.