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Long-term micro/nanoplastic ingestion promotes sepsis by worsening kidney damage: a transcriptomics and metabolomics study
Summary
Researchers found that long-term ingestion of micro- and nanoplastics worsened kidney damage in septic mice and reduced survival rates, with multi-omics analysis identifying five genes — Srm, Pycr2, Arg2, Asns, and Psat1 — as likely key mediators linking plastic exposure to aggravated sepsis outcomes.
Our study finds that smaller-sized plastics affect the survival of septic mice by damaging and aggravating kidney injury. Multi-omics analysis has revealed that five genes—Srm, Pycr2, Arg2, Asns, and Psat1—may play key roles in this process.