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Distinct influence of preservatives on microbial community and resistance gene in bio-carriers biofilm and microplastics biofilm as revealed in sulfur autotrophic denitrification coupled with anammox system

Environmental Research 2026
Ke Zhang, Ke Zhang, Jiajian Gao, Yi Guo, Tian Xie, Zhang Ye, J. Y. Zhang, Tianyi Lu

Summary

Researchers examined how preservatives commonly found in wastewater affect microbial communities on microplastic biofilms versus bio-carrier biofilms in a denitrification system. The study found that co-exposure to methylparaben and benzethonium chloride reduced nitrogen removal efficiency and enhanced the prevalence of antibiotic resistance genes, particularly on microplastic surfaces.

Study Type Environmental

Microplastics (MPs) can act as a carrier of microorganisms and form a distinct ecological niche. Methylparaben (MeP) and benzethonium chloride (BZC) are commonly used as preservatives in daily life and co-exist with MPs in wastewater environment. This study comprehensively examined the diverse characteristics of resistance genes (RGs) and the microbial communities in both bio-carriers biofilm and MPs biofilm, along with the performance variations in sulfur autotrophic denitrification coupled with anammox (SAD/A) under co-exposure to MeP (0.5 mg/L) and BZC (0.5-2 mg/L). Results showed that co-exposure to 0.5 mg/L MeP and 2 mg/L BZC decreased the total nitrogen removal efficiency of SAD/A (from 95.16% to 75.36%). Preservatives exhibited the enhanced effect on the prevalence of intracellular RGs and extracellular RGs, which was stronger in MPs biofilm (1.33 × 10-1.53 × 10 copies/ng DNA) than in bio-carriers biofilm (3.58 × 10-9.08 × 10 copies/ng DNA). Stappia, Microbacterium and Acidovorax identified as pathogenic bacteria, exhibited higher abundance in MPs biofilm (0.46%-2.11%) than in bio-carriers biofilm (0.24%-1.71%). In both bio-carriers biofilm and MPs biofilm, the microbial community assembly was predominantly driven by stochastic processes, with preservatives inducing enrichment of potential RGs hosts. These findings provided important insights into different ecological characteristics of MPs and bio-carriers in SAD/A system under preservatives exposure, which offers references for the management and risk assessment of preservatives and MPs.

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