We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Stimulation of Human Adenovirus Infection Modulated by Emerging Micropollutants
Summary
Researchers tested how pharmaceuticals and nanoplastics affect human adenovirus replication in lung cells under various exposure scenarios. They found that while individual pre- or post-infection exposure had no significant effect, co-incubating the contaminants with viral particles at body temperature significantly increased viral replication by up to 30-fold. The study suggests that emerging contaminants in water environments may enhance viral infectivity through direct physical and chemical interactions.
Contaminants of emergent concern (CECs), such as pharmaceuticals and microplastics, are increasingly found in aquatic environments, yet their interactions with viral pathogens remain underexplored. This study evaluated the effects of antibiotics, antidepressants, microfibers, and nanoplastics on human adenovirus type 5 (HAdV-5) replication in A549 cells. A series of in vitro assays simulating distinct exposure scenarios across the viral replication cycle was conducted. Results showed that individual pre- or post-infection exposure to CECs did not significantly impact HAdV-5 replication. However, co-incubation of CECs with viral particles at physiological temperature (37 °C) led to a significant increase in viral replication up to 1.5 log₁₀ compared to viral control, highlighting temperature-dependent interactions. No enhancement was observed at room temperature. The findings suggest that CECs can modulate viral infectivity through direct physicochemical interactions, particularly under conditions resembling those of wastewater environments. This study provides new insights into the potential risks posed by the co-occurrence of viruses and CECs in aquatic ecosystems.
Sign in to start a discussion.