We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Mechanisms of nanoplastic-induced energy metabolism reprogramming in juvenile Sepia esculenta: mRNA profile, miRNA/mRNA network, and ceRNA network
AI summary Read the abstract
Researchers found that nanoplastics disrupted energy metabolism in juvenile cuttlefish, a popular seafood in China, by suppressing normal energy production pathways and causing oxidative stress. The study used advanced genetic analysis to show how nanoplastics reprogram the way these animals process energy at the molecular level. Since cuttlefish are widely consumed, these effects raise questions about seafood safety in nanoplastic-contaminated waters.
The presence of nanoplastics (NPs) in aquatic environments poses significant threats to the health of aquatic organisms, garnering widespread attention. The Sepia esculenta , known for its high protein content, is a favored seafood among consumers in China. However, studies investigating the harmful effects of NPs on Sepia esculenta remain scarce. Given that juvenile animals are more vulnerable to environmental stressors, we focused our research on juvenile Sepia esculenta and established an NPs exposure model with one control group and two NPs treatment groups. We conducted sequencing of the mRNA, miRNA, and lncRNA transcriptomes across the three groups. In our results, mRNA profiling, along with miRNA/mRNA and lncRNA/miRNA/mRNA network analyses, provided evidence that NPs triggered a reprogramming of energy metabolism. This shift was characterized by the suppression of glycolysis and amino acid metabolism, resulting in reduced ATP synthesis capacity, while simultaneously enhancing GTP metabolism. Furthermore, results from both mRNA profiling and biochemical tests confirmed that NPs induced oxidative stress; interestingly, oxidative stress played a role in mediating the metabolic reprogramming. Importantly, miRNAs and lncRNAs were involved in energy metabolism reprogramming induced by NPs. Our findings will provide novel insights into the effects of environmental pollutants on Sepia esculenta , contributing to the conservation efforts for endangered species within the context of environmental contamination. • NPs poisoning model of juvenile Sepia esculenta was successfully established. • NPs inhibited ATP production capacity, promoted GTP metabolism and caused energy metabolism reprogramming. • miRNAs and lncRNAs were involved in the mechanism of energy metabolism reprogramming. • Oxidative stress mediated energy metabolism reprogramming under NPs stress.
More Papers Like This
Transcriptomic analysis of oxidative stress mechanisms induced by acute nanoplastic exposure in Sepia esculenta larvae
AI summary Read the abstract
Researchers used transcriptomic analysis to reveal that acute nanoplastic exposure in cuttlefish larvae triggered oxidative stress through disruption of antioxidant enzyme gene expression, identifying key molecular pathways affected by plastic pollution in marine cephalopods.
Acute exposure to polystyrene nanoplastics induced oxidative stress in Sepia esculenta Larvae
AI summary Read the abstract
Researchers exposed cuttlefish larvae (Sepia esculenta) to polystyrene nanoplastics and found significant oxidative stress — a type of cellular damage caused by unstable molecules called free radicals — along with changes in the expression of genes involved in stress response pathways. This study extends understanding of nanoplastic harm beyond commonly studied species to economically important marine cephalopods.
Application of transcriptome profiling to inquire into the mechanism of nanoplastics toxicity during Ciona robusta embryogenesis
AI summary Read the abstract
Transcriptome profiling of marine mussels exposed to amino-modified polystyrene nanoplastics was used to develop an adverse outcome pathway (AOP), revealing disruption of immune function, energy metabolism, and cytoskeletal integrity as key molecular events. The integrative approach provides a mechanistic framework for predicting nanoplastic hazards in marine invertebrates.
Gradual effects of gradient concentrations of polystyrene nanoplastics on metabolic processes of the razor clams
AI summary Read the abstract
Researchers exposed razor clams to a gradient of polystyrene nanoplastic concentrations and used metabolomics to track effects, finding that even low concentrations disrupted energy metabolism and amino acid pathways, with effects becoming more severe as concentration increased.
Effects of Acute Exposure to Polystyrene Nanoplastics on the Channel Catfish Larvae: Insights From Energy Metabolism and Transcriptomic Analysis
AI summary Read the abstract
Researchers found that acute exposure to polystyrene nanoplastics disrupted energy metabolism in channel catfish larvae, with transcriptomic analysis revealing altered gene expression in pathways related to oxidative stress and metabolic processes.
Research digests by email
When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.