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A particle of concern: explored and proposed underlying mechanisms of microplastic-induced lung damage and pulmonary fibrosis
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This paper explores how inhaled microplastics may cause lung damage and scarring (pulmonary fibrosis) through several biological pathways. The research identifies signaling pathways that could be targeted for future treatments to reduce microplastic-induced lung damage. This is relevant to human health because people regularly breathe in airborne microplastic particles.
These signaling pathways could also be targeted to reduce microplastic-induced pulmonary fibrosis, opening new avenues for future treatments.
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Microplastics in the Lungs: Exposure Pathways, Pulmonary Deposition, Toxicological Effects, and Carcinogenic Potential
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This review summarizes existing research on tiny plastic particles found in human lungs after breathing them in. Lab studies on plastic particles showed inflammation, cell damage, and genetic damage, while human data remain limited but confirm microplastics are present in lungs, linked to inflammatory and fibrotic lung conditions.
Breathing under siege: a narrative review on the potential biological mechanisms linking micro- and nanoplastic exposure to lung diseases
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This narrative review examines how inhaled micro- and nanoplastics from indoor and outdoor air — including from synthetic textiles and face masks — can trigger lung inflammation, oxidative stress, and fibrosis, and outlines proposed mechanisms linking plastic inhalation to respiratory disease.
An emerging role of microplastics in the etiology of lung ground glass nodules
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This study proposes a mechanistic link between microplastic inhalation and the development of pulmonary ground glass nodules, reviewing evidence that inhaled microplastics may trigger inflammatory and fibrotic processes in lung tissue.
Pathophysiological effects of inhaled airborne microplastics on the respiratory epithelial barrier: A review
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Tiny plastic particles floating in the air we breathe may be doing more damage to our lungs than we realized. This review of existing research found that when these microplastics land in our airways, they can trigger cell stress, inflammation, and damage to the protective lining of our lungs—potentially making respiratory problems worse over time. While scientists still need more long-term studies to fully understand the risks, this research is an early warning sign that the plastic pollution in our air isn't just an environmental issue—it could be a health issue too.
Intratracheal Administration of Polystyrene Micro(nano)plastics with a Mixed Particle Size Promote Pulmonary Fibrosis in Rats by Activating TGF-β1 Signaling and Destabilizing Mitochondrial Dynamics and Mitophagy in a Dose- and Time-Dependent Manner.
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SD rats exposed to mixed polystyrene micro(nano)plastics via intratracheal administration at escalating doses over time developed pulmonary fibrosis and mitochondrial dysfunction, with severity linked to dose. The findings demonstrated a clear biological pathway connecting inhaled microplastic exposure to lung injury.
Research digests by email
When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.