We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Exposure to Nanoplastics During Pregnancy Induces Brown Adipose Tissue Whitening in Male Offspring
AI summary Read the abstract
Researchers found that exposing pregnant mice to polystyrene nanoplastics caused changes in the brown fat tissue of their male offspring, shifting it toward white fat characteristics associated with obesity. This transformation was driven by disruptions in fat production and a cellular recycling process called lipophagy. The study suggests that nanoplastic exposure during pregnancy could increase obesity risk in offspring by altering how their bodies regulate fat storage and energy burning.
These findings indicate that gestational PSNP exposure plays a role in the development of obesity in offspring through the whitening of brown adipose tissue, which is triggered by lipogenesis and lipophagy inhibition, providing a novel insight into the metabolic risks associated with gestational PSNPs exposure.
More Papers Like This
Maternal polystyrene nanoplastics exposure during pregnancy induces obesity development in adult offspring through disrupting lipid homeostasis
AI summary Read the abstract
Researchers found that maternal inhalation exposure to polystyrene nanoplastics during pregnancy induced obesity development in adult offspring of mice, suggesting in utero exposure to airborne nanoplastics programs metabolic dysfunction. The study linked prenatal nanoplastic exposure to increased adiposity and metabolic changes persisting into adulthood.
Maternal nanoplastic ingestion induces an increase in offspring body weight through altered lipid species and microbiota
AI summary Read the abstract
Researchers found that when mother mice ingested nanoplastics derived from polystyrene and polypropylene during pregnancy and nursing, their offspring showed increased body weight gain. The weight changes were associated with alterations in fat metabolism and shifts in gut microbiome composition in the pups. The study suggests that maternal exposure to nanoplastic pollution may act as an environmental factor contributing to weight gain in offspring.
Effects of polystyrene nanoplastic gestational exposure on mice
AI summary Read the abstract
Researchers exposed pregnant mice to airborne polystyrene nanoplastics and studied the effects on both mothers and offspring. High-dose exposure caused fatty liver disease in the mothers and in adult female offspring, but not in male offspring, with each group showing different underlying molecular mechanisms. The study suggests that prenatal exposure to airborne nanoplastics may have sex-specific effects on metabolic health that persist into adulthood.
Maternal Gestational and Lactational Exposure to Polystyrene Nanoplastics Triggers Vascular Injury and Lipid Deposition in Mouse Offspring
AI summary Read the abstract
Pregnant and nursing mice were given polystyrene nanoplastics in water. Their offspring showed lower body weight, organ damage, and blood vessel injury including fat buildup in the aorta, with some effects persisting into adulthood. Nanoplastics also caused fat accumulation in lab-grown blood vessel and immune cells.
Exposure to polystyrene nanoplastics impairs sperm metabolism and pre-implantation embryo development in mice
AI summary Read the abstract
This study found that male mice given polystyrene nanoplastics by mouth showed significant harm to sperm function and early embryo development, with changes in gene expression that could affect offspring. The findings raise concerns that nanoplastic exposure could impair male fertility and potentially pass harmful effects to the next generation.
Research digests by email
When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.