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Multimodal multiphoton tomography in cosmetic research
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This paper reviews 20 years of multiphoton tomography applications in cosmetic research, including non-invasive imaging of human skin and detection of cosmetic ingredients. The technique can detect fluorescent microplastic particles in skin samples and has enabled safety evaluation of various topical formulations without skin biopsies.
Over the past two decades, certified multiphoton femtosecond laser tomographs have been used for non-invasive, high-resolution in vivo imaging of human skin by enabling (i) the detection of autofluorescent coenzymes, keratin, melanin, and elastin, (ii) second harmonic generation (SHG) of collagen, and (iii) autofluorescence lifetime imaging. Beyond its application in the detection of malignant melanoma, first MPT studies were focused on evaluating skin modifications induced by the topically applied cosmetic products. Notable applications include assessing long-term anti-ageing effects through changes in the elastin-collagen-ratio, as well as short-term effects by influencing the epidermal NADH level with antioxidants, measured using optical metabolic imaging (OMI). Furthermore, the accumulation sites and penetration depths of ZnO sunscreen nanoparticles and cosmetic microplastics in skin have been investigated. Nowadays, the multimodal ultracompact fiber laser tomograph MPTcompact (Prism Award Winner 2024) that integrates also reflectance confocal microscopy (RCM), is employed by the cosmetic industry in Japan and Europe, providing additional insights into skin health and effectiveness of cosmetic products.
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Multiphoton Tomography in Cosmetic Research
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This review describes how multiphoton tomography, a high-resolution laser imaging technique, is being used in cosmetic research to study skin at the cellular level without invasive biopsies. The technology can track how cosmetic ingredients including sunscreen nanoparticles and micro- and nanoplastics distribute within skin tissue. It provides a powerful tool for evaluating product safety and efficacy, including understanding how tiny plastic particles from cosmetic formulations interact with living skin.
Multiphoton Tomography in Cosmetic Research
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This review examined multiphoton tomography (MPT)—a non-invasive femtosecond laser imaging technique—as a tool for cosmetic research, enabling high-resolution visualization of cellular metabolism and structural changes in human skin. MPT was presented as a powerful method for studying how cosmetic ingredients, including microplastic-containing formulations, interact with skin cells.
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