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Microplastics: a cancer-causing agent for humans and prospects for identification using AI and modern approaches

Discover Oncology 2025 4 citations

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Tiny plastic particles called microplastics, smaller than a grain of rice, some invisible to the eye, can get into your body through the air you breathe, the food you eat, and even your skin, where they may trigger harmful biological reactions linked to cancer risk. This review paper pulls together existing research on how these particles behave in the body and highlights promising AI-based tools that could help scientists detect and study microplastics more effectively. The takeaway: microplastics are a growing health concern worth watching, and better detection methods are key to understanding the real risks they pose.

Microplastics (MPs) are synthetic/polymeric particulate solids having a regular shape with dimensions ranging from 1 µm to 5 mm and hydrophobic nature [ 1 ]. However, microplastics can be of irregular shapes as well. Most MPs in various ecosystems are secondary, weathered MPs, which often exhibit very irregular and unusual shapes. The major source of MPs in the environment is due to their non-biodegradable nature, which is poorly biodegradable or decomposed completely and narrowed down in soil or water in a very micro-size range [ 2 ]. These plastics can enter the body via three pathways i.e., inhalation, ingestion and skin. Cellular uptake involves a regulated mechanism with complex biomolecular interactions and this uptake results in a biological response which results in the toxic effects of these MPs (Fig. 1 ) [ 3 ].

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