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3C-labeled nanoplastic model materials: Synthesis and evaluation of potential uses for experimental works through bioaccumulation test studies in aquatic crustaceans
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Researchers synthesized carbon-13 labeled nanoplastic model materials and validated their use for studying bioaccumulation in freshwater crustaceans using isotope ratio mass spectrometry. The labeled nanoplastics enabled precise quantification of uptake and depuration without interference from background environmental plastic, providing a new tool for nanoplastic toxicokinetic studies.
Considerable advances have been made recently to quantify nanoplastics in the environment but complex matrices such as biota remains a challenge. We propose for the first time, a labeling strategy to quantify nanoplastics in complex matrices, without any interferences or extensive sample preparation, using an elemental analyzer coupled with an isotope ratio mass spectrometry (EA-IRMS) and compared to Pyrolysis gas chromatography mass spectrometry (Py-GC/MS), to study the uptake of nanoplastics in aquatic crustacea.13C-labeled nanoplastic model materials were synthetized mimicking naturally aged plastics and ensuring their stability in a wide range of media, from freshwaters to seawater. Aquatic crustaceans (Artemia sp.) were exposed to these nanoplastic model materials at different concentrations, including environmentally realistic ones. The uptake was directly related to the exposure time and concentration, with a tendency of higher accumulation in females. The depuration kinetics indicated a depuration in two steps. Our study demonstrates the potential of 13C-labeling, associated with EA-IRMS detection, and offers a new labeling strategy to quantitatively track nanoplastics in complex matrices, strategy that could be applied to a wide range of experiments and in the same way to other stable isotopes. This approach allows for an increased understanding of the impacts of nanoplastics on marine organisms under realistic exposure conditions, through the development of analytical protocols, with detection limits (LOD) and quantification limits (LOQ) reaching 2 mg.kg⁻¹ and 7 mg.kg⁻¹, respectively, in aquatic crustaceans.
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13C-labeled nanoplastic model materials: Synthesis and evaluation of their use in ecotoxicology through bioaccumulation studies in aquatic crustaceans
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Researchers developed carbon-13 labeled nanoplastic particles as a new tool for accurately tracking and measuring nanoplastics in living organisms. By combining stable isotope labeling with mass spectrometry, they could detect nanoplastics in complex biological samples like brine shrimp without the extensive sample preparation that current methods require. The approach provides a more reliable way to study how nanoplastics accumulate in aquatic food chains.
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This study developed labeled nanoplastic model materials using isotopic and metallic tracers to enable tracking and quantification of nanoplastics in complex biological and environmental matrices at environmentally relevant concentrations. Labeled particles allowed localization and measurement of nanoplastics at levels not detectable by conventional methods, advancing mechanistic exposure studies.
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Researchers synthesized isotopically and metallically labeled nanoplastic model materials to enable tracking and quantification of plastic nanoparticles in complex biological and environmental matrices at trace concentrations. The labeled models supported mechanistic studies of nanoplastic fate and exposure by allowing detection at environmentally relevant concentrations not achievable with conventional unlabeled particles.
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Researchers developed a method to synthesize carbon-14 labeled polyethylene terephthalate (PET) and generate radiolabeled nanoparticles for tracking plastic fate in biological systems. The approach combines polycondensation chemistry with nanoprecipitation to produce well-characterized nanoparticles. This tool could enable researchers to study how PET micro- and nanoplastics are absorbed and distributed in the tissues of food animals, addressing a major knowledge gap in understanding plastic exposure through the food chain.
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