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Determination of Cancerogenic Potentials Microplastic and recycled plastic on Oreochromis niloticus using Micronucleus Assay
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Researchers used the micronucleus assay in Nile tilapia erythrocytes to assess the genotoxic and carcinogenic potential of microplastics and recycled plastic leachates. Both types caused significant increases in micronucleus frequency in a dose-dependent manner, indicating that plastic-associated chemicals can induce chromosomal damage in fish cells.
Micronuclei (MN) play a fundamental role during cancer evolution and metastatic progression. Water pollution means that these bodies are polluted with harmful substances, resulting in serious health hazards. Microplastics are currently a significant source of global concern. Environmental exposures are known risk factors for cancer etiology. These carcinogens also accumulate in aquatic organisms consumed by humans, eventually entering our food chain. In our study, the effects of microplastic (MP) and recycled plastic (RP = plastic bottle caps) concentrations on the erythrocytes of the fish Oreochromis niloticus (Nile Tilapia) were investigated for their carcinogenic and hematological effects on red blood cells (RBCs) through MN testing and erythrocyte counting. The results indicated that, due to the effects of MP and RP concentrations, the frequency of MN in erythrocytes increased in a concentration- and time-dependent manner, leading to cancer in living organisms and causing a decrease in the number of red blood cells (anemia).
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Evaluation of Toxicological Risks and Effects of Microplastics on Nile Tilapia (Oreochromisniloticus) under in Vitro Laboratory Conditions
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Genotoxic and cytotoxic effects of polyethylene microplastics on human peripheral blood lymphocytes
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Researchers tested whether polyethylene microplastics cause genetic damage to human blood cells using a specialized laboratory assay. The study found that even low concentrations of microplastics significantly increased markers of genomic instability, including micronucleus formation and other indicators of DNA damage. This is among the first studies to demonstrate that microplastics have genotoxic potential in human cells, though the particles did not appear to kill the cells outright.
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Researchers found that microplastic exposure in juvenile Nile tilapia caused dose-dependent increases in eryptosis (red blood cell apoptosis) and poikilocytosis (abnormal cell shapes), establishing these as novel biomarkers for assessing microplastic toxicity in fish.
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When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.