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Peptide-based strategies for detecting microplastics in aquatic systems: A review

Trends in Environmental Analytical Chemistry 2025 2 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Abbas Motalebizadeh, Somayeh Fardindoost, Mina Hoorfar

Summary

This review explores the emerging use of specially designed peptides that can bind to specific types of plastic for detecting microplastics in water. Researchers describe how advances in protein engineering and computational design have enabled the creation of peptides that selectively recognize different polymer surfaces. The peptide-based approach offers a promising new detection method that could complement existing techniques for monitoring microplastic pollution in aquatic environments.

Microplastics, defined as plastic particles less than 5 mm in diameter, have become pervasive pollutants in marine and terrestrial environments and pose significant environmental and health risks, necessitating effective detection methods. The selective detection of these tiny particles is challenging due to the complexity of the matrices of marine water. This mini-review explores the significant advancements and applications of microplastic-binding peptides, underlining their potential as a novel approach for microplastic detection and highlighting their specificity, sensitivity, and versatility. Progress in this field has been driven by advances in protein engineering, computational techniques, and analytical methodologies, enabling the design of plastic-specific peptides with fine-tuned binding properties. We discuss the current state of research, challenges, and future directions in this emerging field.

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