We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Determination of IC50 of Advanced nanomaterials (Ad-NMs) and nano-microplastics (NMPs) in vivo, in C. elegans v1
AI summary Read the abstract
This study describes a method for testing how toxic advanced nanomaterials and nano-sized microplastics are to tiny worms called C. elegans, which are often used to study effects on living animals. These worms are considered useful stand-ins for studying human and environmental health because their biology shares similarities with mammals and their bodily systems remain intact and functioning during testing.
The acute toxicity of advanced nanomaterials (Ad-NMs) and nano-microplastics (NMPs) in vivo was evaluated in the nematode Caenorhabditis elegans (C. elegans), which is widely used to assess the effects of nanomaterials of various shapes and sizes. This nematode is a reliable model for human pathophysiology because it exhibits toxic modes of action similar to those of mammals. C. elegans was selected not only for its well-conserved signal pathways and its high level of gene homology with humans, but also because it can be used to obtain helpful information regarding the toxicity of Ad-NMs and NMPs for environmental health (particularly for terrestrial and aquatic animals). The nematode is ubiquitous worldwide and can live in both soil and water. Data on worms provide information from a whole-animal perspective, with intact, metabolically active digestive, reproductive, endocrine, sensory, and neuromuscular systems.
More Papers Like This
Determination of sub-acute toxicity of advanced nanomaterials and nano-microplastics in vivo in C. elegans v1
AI summary Read the abstract
This paper describes a method for testing how tiny engineered materials and nano-sized plastic particles affect a small worm called C. elegans, which scientists use as a stand-in for studying effects in animals and humans. The worm has organ systems similar to larger animals, making it useful for studying effects on environmental and animal health.
C. elegans as a powerful model for neurotoxicity assessment
AI summary Read the abstract
This review highlights the roundworm C. elegans as a valuable model organism for studying how toxic substances, including microplastics and nanoplastics, affect the nervous system. The worm's simple but well-mapped nervous system allows researchers to observe neurological damage at the cellular and molecular level. The study notes that C. elegans research has been instrumental in identifying how environmental pollutants can impair nerve function, memory, and behavior.
Experimental methods for assessing the effects of microplastics on Caenorhabditis elegans : a scoping review
AI summary Read the abstract
This review examined 59 published lab studies that used tiny worms called C. elegans to test microplastic effects. Most studies used simple, unweathered plastic particles of one shape and polymer type, short exposure times, and a single dose, which differs from the varied plastics found in the real environment.
A review of the reproductive toxicity of environmental contaminants in Caenorhabditis elegans
AI summary Read the abstract
Researchers review how a tiny roundworm called Caenorhabditis elegans is used to study the reproductive harm caused by environmental pollutants — including microplastics, heavy metals, and nanomaterials. Because this worm shares many genes with humans and reproduces quickly, it is a valuable early-warning system for identifying contaminants that could threaten fertility across species.
The Toxicity of (Nano)Microplastics on C. elegans and Its Mechanisms
AI summary Read the abstract
Researchers reviewed the toxicological effects of micro- and nanoplastics on the model organism Caenorhabditis elegans, finding that these particles cause oxidative stress, reproductive impairment, developmental delays, and neurological dysfunction, with nanoplastics generally more toxic than microplastics due to their greater cellular penetration.
Research digests by email
When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.