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Adverse Effects of Nanoplastics Administration on the Metabolic Profile and Glucose Control in Mice
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This systematic review examines how nanoplastic exposure in mice affects metabolism and blood sugar control. The findings suggest that ingesting nanoplastics may disrupt metabolic processes and glucose regulation in mammals, raising concerns about potential links between everyday plastic exposure and metabolic health conditions like diabetes in humans.
Results: We identified and screened 76,587 articles, of which 10,884 were included.Research addressed agricultural processes for crops (73% of articles), seafood (21%) and meats (8%) from more than 140 countries.Most research assessed cadmium (68%), followed by lead (44%), arsenic (24%), and mercury (15%).Most articles on crops (57%) focused on soil, soil amendments, and fertilizer.Whereas most articles on seafood (49%) and meat (39%) were related to weather and the environment, including pollution.Five agricultural process categories from each domain were determined to be research gaps.For crops, these were planting and field maintenance (6% of articles), microbial inoculation (5%), harvesting (2%), washing, storage, and waste management (2%), and pest control (1%).Gaps for seafood were on feed (9%), medications and feed additives (3%), chemotherapeutants in water (1%), fertilizer (0.4%), biologics and hormones to induce spawning (0.1%).For meats, gaps included egg production (4%), housing (3%), milk production (2%), reproduction (1%), and farm management, waste, and production scale (0.4%).Conclusions: Our study identified several research gaps warranting further investigation, as well as areas where existing evidence might be sufficient to warrant systematic review to inform future policies related to reducing heavy metal contaminants in the global food supply.
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Effects of oral administration of polystyrene nanoplastics on plasma glucose metabolism in mice
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Researchers fed polystyrene nanoplastics to mice and tracked their accumulation in organs including the liver, kidneys, and pancreas. They found that the nanoplastics disrupted liver function, altered lipid metabolism, and affected blood glucose regulation. The study suggests that nanoplastic ingestion may interfere with metabolic processes, raising concerns about potential endocrine-related health effects.
Exploring the micro- and nanoplastics–diabetes nexus: Shattered barriers, toxic links, and methodological horizons
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This review examines growing evidence that micro- and nanoplastics may contribute to diabetes by disrupting blood sugar regulation, insulin signaling, and fat metabolism through oxidative stress and inflammation. Animal studies show that plastic particles can damage the pancreas, liver, and gut in ways that mirror the development of diabetes, though human studies are still limited. The review calls for more research into whether everyday microplastic exposure could be a hidden factor in the global rise of metabolic diseases.
Micro- and nanoplastic impact on insulin resistance and related metabolic disorder in rodents: A systematic review
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This systematic review examined whether micro- and nanoplastics contribute to insulin resistance in animal studies. The findings suggest that polystyrene plastic particles can disrupt how the body processes sugar and responds to insulin, pointing to a possible link between plastic exposure and metabolic disorders like type 2 diabetes.
The effect and a mechanistic evaluation of polystyrene nanoplastics on a mouse model of type 2 diabetes
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Researchers found that polystyrene nanoplastics worsened type 2 diabetes symptoms in mice, including blood sugar control, insulin resistance, and organ damage in the liver and pancreas. Even nanoplastics alone, without a high-fat diet, caused significant increases in blood glucose and insulin resistance at higher doses. The study reveals a specific molecular pathway through which nanoplastics disrupt blood sugar regulation, raising concerns that chronic human exposure to nanoplastics could contribute to metabolic diseases like diabetes.
Biological exposure to microplastics and nanoplastics and plastic additives: impairment of glycolipid metabolism and adverse effects on metabolic diseases
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This review examines how exposure to micro- and nanoplastics disrupts the body's ability to process sugars and fats, potentially contributing to diabetes, obesity, and atherosclerosis. The plastics cause inflammation and oxidative stress, damage gut bacteria, trigger insulin resistance, and increase fat buildup in the liver. For people who already have metabolic conditions, plastic exposure may make their disease worse.
Research digests by email
When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.