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Author response for "Validating AIEgen-Labeled Nanoplastics as Silent Tracers to Elucidate Surface Charge-Dependent Transcriptomic Divergence in Hepatotoxicity"

2026

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Body Systems

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The effects of nanoplastics on toxicity of metals and metal nanoparticles: molecular mechanisms and health effects

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Researchers reviewed how co-exposure to nanoplastics and heavy metals produces synergistic toxicity across multiple species and cell models, finding that nanoplastics enhance metal bioavailability and amplify oxidative stress, mitochondrial dysfunction, apoptosis, and gut dysbiosis more severely than equivalent microplastic co-exposures.

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