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Resveratrol in Microplastic‐ and Nanoplastic‐Induced Toxicity: Current Evidence, Mechanistic Insights, and Future Directions
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This review paper summarizes existing research on how tiny plastic particles called microplastics and nanoplastics may harm cells, and how resveratrol, a plant compound found in grapes and berries, might affect related cell signaling pathways. The authors note that this evidence comes only from a small number of lab studies in animals or cells, with no human studies, so the proposed effects remain unconfirmed.
Microplastic (MP; MPs) and nanoplastic (NP; NPs) pollution poses a growing threat to global health. Their small size and large surface area facilitate ingestion, accumulation, and interactions with biological systems, leading to toxicity through oxidative stress, inflammation, mitochondrial dysfunction, and cell death. These effects may occur directly or through the release of adsorbed pollutants and plastic additives. Resveratrol (3,5,4'-trihydroxy-trans-stilbene; RV), a natural polyphenol found in grapes, berries, and peanuts, has attracted interest as a potential protective agent because of its antioxidant and anti-inflammatory properties. Its proposed protective effects against MP/NP toxicity involve modulation of key cellular signaling pathways, particularly nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor-kappa B (NF-κB). RV may activate Nrf2 by disrupting its interaction with Kelch-like ECH-associated protein 1 (Keap1), thereby enhancing antioxidant defenses, including superoxide dismutase, catalase, and glutathione peroxidase, and reducing reactive oxygen species-mediated damage to lipids, proteins, and DNA. Concurrently, RV may suppress NF-κB-mediated inflammatory responses. However, current evidence is limited to a small number of preclinical studies, with no human studies available. These mechanisms remain largely hypothetical and require validation using standardized MP/NP exposure models.
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Avaliação do efeito de citotoxicidade dos microplásticos na linhagem mamária humana MCF10A
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Researchers assessed the cytotoxicity of microplastics on the non-tumoral human breast cell line MCF10A and explored whether the antioxidant resveratrol could mitigate those effects. The study found that microplastics negatively impacted cell viability and that resveratrol showed potential as a protective agent in the cellular context of MP exposure.
Cellular responses to micro- and nanoplastics exposure: mechanisms and pathophysiological implications
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This review summarizes existing research on how tiny plastic particles interact with cells in lab and animal studies, finding repeated signs of cell stress, including damage to cell structures and inflammation. Studies also detected plastic material in human blood and tissue samples, but the review states this does not prove the particles cause specific diseases.
Microplastics and Nanoplastics in Health Concerning Cellular Toxicity Mechanisms, Exposure Pathways, and Global Mitigation Strategies
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This review synthesizes current knowledge on how micro- and nanoplastics cause cellular damage in the human body, covering mechanisms like oxidative stress, inflammation, DNA damage, and disruption of cell signaling pathways. Researchers note that exposure occurs through multiple routes including ingestion and inhalation, allowing particles to reach organs throughout the body. The study highlights significant gaps in understanding long-term and low-dose exposure effects that are most relevant to everyday human contact with these particles.
Impact of microplastics and nanoplastics on human Health: Emerging evidence and future directions
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This review summarizes current evidence on how micro- and nanoplastics enter the human body through food, air, and skin contact, and the cellular damage they may cause. While microplastic pollution is a recognized environmental hazard, the authors note that definitive evidence linking plastic particle exposure to specific health outcomes in humans is still limited and more realistic exposure studies are needed.
Microplastics and nanoplastics: Characterizing potential health perturbations and mechanistic evidence
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Tiny plastic particles called microplastics and nanoplastics are everywhere, in our food, water, and air, and this review pulls together existing research on how they might harm our bodies. Scientists found these particles can damage cells, trigger inflammation, disrupt gut bacteria, and may even raise cancer risk, though more research is still needed to fully confirm these links in humans. The takeaway: reducing plastic exposure in daily life is a reasonable precaution while researchers work to better understand the risks.
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