Aggravated neurotoxicity of combined exposure to photoaged PS-NPs and Cr(VI) in zebrafish: A comprehensive study from behavior to transcriptome

Toxicity and behavioral response of zebrafish exposed to combined microplastic and bisphenol analogues

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Co-exposure of zebrafish larvae to polystyrene microplastics combined with bisphenol A or F increased larval lethality by 7–51% compared to either pollutant alone, while also causing stronger behavioral effects including reduced movement and activity. This synergistic toxicity — not seen in embryos — highlights the danger of treating microplastics and chemical contaminants as independent hazards, since real-world exposures are always mixed.

Simulated Environmental Nanoplastics Induce Zebrafish Developmental Toxicity and Stress Response

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Scientists exposed zebrafish embryos to nanoplastics that were specially broken down to mimic how plastic actually degrades in oceans and rivers, and found they caused more harm than the lab-made plastic beads typically used in research, stunting growth, slowing hatching, and triggering stress hormone spikes even at very low doses. Because these effects showed up at concentrations similar to what's found in real water sources, the findings suggest current safety testing may be underestimating the risks nanoplastics pose to both aquatic life and, potentially, to people who drink that water or eat seafood from it.

Multi-omics Elucidates Convergent and Concentration-Specific Toxicity Mechanisms Underlying Muscle Dysfunction and Locomotor Impairment In Large Yellow Croaker Exposed to Nanoplastics