0
Article Tier 2 Sign in to save

P20-20 An AI-guided human serum-derived educated liver spheroid platform for contextualizing nanoplastics-induced hepatotoxicity risk

No summary available — this paper's abstract is not included in the open metadata provided by the publisher. Learn why →

Body Systems

More Papers Like This

Article Tier 2

A computational framework for multi-scale data fusion in assessing the associations between micro- and nanoplastics and human hepatotoxicity

AI summary Read the abstract

Researchers developed a computational toxicology framework integrating multi-source data and network analysis to map associations between micro- and nanoplastics and hepatotoxicity, identifying key molecular pathways through which MNPs may damage the liver, offering a scalable alternative to traditional in vivo testing.

Article

20260228 Dietary microplastic impair liver regeneration

AI summary Read the abstract

This research reviewed clinical evidence on the health impacts of microplastic exposure in humans, synthesizing findings from biomonitoring studies, epidemiological investigations, and in vitro toxicology. The review identifies associations between microplastic body burden and inflammatory outcomes, while noting significant gaps in long-term exposure studies.

Article

20260228 Dietary microplastic impair liver regeneration

AI summary Read the abstract

This study examined the impacts of plastic pollution on marine life in Palawan, Philippines, documenting plastic ingestion and entanglement in local fish, sea turtles, or other marine species. The findings highlight the ecological toll of inadequate waste management in a globally recognized biodiversity hotspot.

Article Tier 2

In vitro toxicity of polyethylene terephthalate nanoplastics (PET-NPs) in human hepatocarcinoma (HepG2) cell line

AI summary Read the abstract

Exposure of HepG2 human liver cells to PET nanoplastics for 72 hours caused dose-dependent reductions in cell viability, oxidative stress at higher concentrations, and significant DNA damage via comet assay, with an IC50 of 616.7 µg/mL. These in vitro findings indicate that PET nanoplastics — shed from the world's most widely used plastic — have genotoxic and cytotoxic potential in human liver tissue, warranting further investigation of carcinogenic risk at environmentally relevant concentrations.

Research digests by email

When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.

Email me about

Share this paper