P09-29 Integrated assessment of behavioral effects and vector potential of emerging contaminants adsorbed onto microplastics in zebrafish

Toxicity and behavioral response of zebrafish exposed to combined microplastic and bisphenol analogues

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Co-exposure of zebrafish larvae to polystyrene microplastics combined with bisphenol A or F increased larval lethality by 7–51% compared to either pollutant alone, while also causing stronger behavioral effects including reduced movement and activity. This synergistic toxicity — not seen in embryos — highlights the danger of treating microplastics and chemical contaminants as independent hazards, since real-world exposures are always mixed.

Recent advances of microplastics toxicity and fate on zebrafish-a review

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This review synthesizes evidence on how micro- and nanoplastics cause developmental, reproductive, gastrointestinal, and oxidative stress toxicity in zebrafish, positioning the species as a valuable vertebrate model for understanding plastic pollutant effects across trophic levels. Zebrafish research is accelerating mechanistic understanding of how microplastics harm vertebrate biology, providing insights relevant to assessing risks for fish-eating wildlife and humans.

Bioaccumulation and Toxic Effects of Micro- and Nanoplastics in Zebrafish: A Critical Review

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Researchers comprehensively reviewed micro- and nanoplastic bioaccumulation and toxicity in zebrafish, finding that these particles accumulate in digestive organs, gills, liver, and brain, inducing oxidative stress, developmental delays, neurotoxicity, and transgenerational reproductive impairments that highlight broad ecological risks.

Toxicity assessment of environmentally relevant microplastics and tire particles on adult zebrafish (Danio rerio)

Acute Effects of Size Dependent Low-Density Polyethylene Microplastics on Zebrafish

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Zebrafish embryos exposed to low-density polyethylene microplastics for 48 hours accumulated particles in their gut, experienced reduced hatching rates, increased heart rates, and significant tissue damage, with smaller particles causing the most harm. These acute effects in a widely used model organism suggest that even brief early-life exposure to plastic particles can disrupt normal development.