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Nano- and Microplastics and Gastrointestinal Toxicity

Chemical Research in Toxicology 2026
Sarawut Sangkham, Anh Tuan Ta

Summary

Tiny plastic particles from packaging, water, and even the air we breathe are increasingly ending up in our bodies, and this review pulls together what scientists currently know about how that might affect our gut health. Early research suggests these particles could trigger inflammation, disrupt the healthy bacteria in our digestive system, and interfere with normal metabolism—but researchers stress that we still don't have enough solid data on real-world human exposure to know exactly how risky this is. The takeaway: microplastics in our gut are a legitimate health concern worth watching, but the science is still catching up to the scale of the problem.

Models

Increasing global plastic production has intensified human exposure to nano- and microplastics (NMPs) through food, water, and air. Emerging evidence links NMP exposure to oxidative stress, inflammation, microbiome disruption, and metabolic dysfunction, although human exposure and health risk data remain limited.

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