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A comparative review of microplastic remediation strategies: constraints of physical and chemical approaches and opportunities for synthetic biology

Frontiers in Synthetic Biology 2026
Hening Guo, Tsz Yam Liu, Tianlin Wen, Mingce Yang, Yihong Zhang, Boxuan Tu

Summary

Microplastics are everywhere, but current cleanup methods have real downsides: physical filtering just moves the plastic bits elsewhere instead of destroying them, and chemical treatments that break them down often use lots of energy and can create new harmful byproducts. This review paper looks at an emerging alternative — using genetically engineered microbes designed to actually digest plastic — which could offer a cleaner, more targeted way to eliminate microplastics from water and soil rather than just relocating the problem. While this approach is still developing, it matters because fewer microplastics in our environment means less of this pollution ending up in our food, water, and e

Microplastic pollution has emerged as a critical environmental challenge, yet existing remediation strategies remain limited in their ability to achieve more complete mineralization under environmentally relevant conditions. In this review, we examine different physical, chemical, and synthetic biology-based methods of microplastic remediation in terms of degradation efficiency, environmental safety, and applicability. The physical techniques can be used to obtain efficient particle removal, but they often lead to shifting contaminants from one environmental matrix to another rather than eliminating them. Chemical approaches enable partial polymer degradation, but they often require energy-intensive processes and generate secondary products. In contrast, synthetic biology-based strategies offer opportunities for a more selective, programmable, and even sustainable breakdown of polymers under less harsh conditions. More precisely, genetically engineered microbes and biological systems can increase the selectivity of such processes while minimizing the impact of traditional techniques on the environment. This review examines the possibilities as well as the constraints of using synthetic biology for microplastic remediation, along with its complementation by physical and chemical treatment strategies.

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