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Pharmaceuticals and Microplastics in Aquatic Environments: A Comprehensive Review of Pathways and Distribution, Toxicological and Ecological Effects
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This review examines how pharmaceuticals and microplastics travel through the environment and accumulate in aquatic food chains, with drug residues found at measurable levels in surface waters and microplastics reaching densities of up to a million particles per cubic meter in some water systems. When aquatic organisms absorb these combined pollutants, the contaminants can biomagnify up the food chain to humans, affecting growth, reproduction, and immune function.
Pharmaceuticals and microplastics are persistent emerging contaminants that pose significant risks to aquatic ecosystems and ecological health. Although extensively reviewed individually, a comprehensive, integrated assessment of their environmental pathways, bioaccumulation dynamics, and toxicological impacts remains limited. This review synthesizes current research on the environmental fate and impact of pharmaceuticals and microplastics, emphasizing their combined influence on aquatic organisms and ecosystems. This review provides a thorough and comprehensive examination of their predominant pathways, sources, and distribution, highlighting wastewater disposal, agricultural runoff, and atmospheric deposition. Studies indicate that pharmaceuticals, such as antibiotics and painkillers, are detected in concentrations ranging from ng/L to μg/L in surface waters, while MPs are found in densities up to 106 particles/m3 in some marine and freshwater systems. The toxicological effects of these pollutants on aquatic organisms, particularly fish, are discussed, with emphasis on bioaccumulation and biomagnification in the food chain, physiological effects including effects on growth, reproduction, immune system performance, and behavioral changes. The ecological consequences, including disruptions to trophic dynamics and ecosystem stability, are also addressed. Although valuable efforts, mitigation and remediation strategies remain inadequate, and further research is needed because they do not capture the scale and complexity of these hazards. This review highlights the urgent need to advance treatment technologies, establish comprehensive regulatory frameworks, and organize intensive research on long-term ecological impacts to address the environmental threats posed by pharmaceuticals and microplastics.
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Pharmaceuticals and Microplastics in Aquatic Environments: A comprehensive Review of Pathways and Distribution, Toxicological and Ecological
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This review examines how pharmaceuticals and microplastics travel through aquatic environments via wastewater, agricultural runoff, and air, and how they affect fish and other aquatic life. Both pollutants build up in the food chain through a process called biomagnification, potentially reaching humans who eat seafood. The authors call for better monitoring and treatment methods to reduce these emerging threats to water quality and public health.
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This systematic review examines how microplastics and nanoplastics in water can absorb and carry pharmaceutical drugs, creating a combined pollution threat. When medications attach to tiny plastic particles in rivers and oceans, they may become more harmful to aquatic life and potentially to humans who consume contaminated seafood or water. The research traces how this emerging double-threat has grown since 2018 and identifies key knowledge gaps.
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Researchers reviewed how microplastics act as "vectors" for pharmaceutical contaminants in aquatic environments, absorbing drugs onto their surfaces and then releasing them inside organisms after ingestion — potentially amplifying the toxicity of pharmaceuticals throughout the food web.
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