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Optical sieve for nanoplastic detection, sizing, and counting: improved detection efficiency through principal component analysis

2026
Dominik Ludescher, Bekim Hisenaj, Lukas Wesemann, Julian Schwab, Julian Karst, Shaban B. Sulejman, Monika Ubl, Brad O. Clarke, Ann Roberts, Harald Giessen, Mario Hentschel

Summary

Scientists have developed a new tool called an "optical sieve" that can detect, measure, and count nanoplastics—tiny plastic particles smaller than 1 micrometer that are too small for most current detection methods to catch reliably. These particles can end up in our food and water and accumulate in body tissues, so having a better way to spot them matters for understanding potential health risks. This paper explains how adding a data analysis technique called principal component analysis makes the tool even better at telling real plastic particles apart from background noise, improving accuracy.

Plastic pollution is widely recognized as one of the most pressing global environmental challenges of the 21st century. The accumulation of plastic debris, its progressive fragmentation over time, and the direct release of nanoplastics have emerged as critical concerns. Once introduced into the environment, these particles can infiltrate the food chain, accumulate in biological tissues, and pose long-term risks to ecosystems as well as human health. Although substantial progress has been made in detecting plastic contaminants, the reliable detection and characterization of particles with diameters below 1µm remain particularly challenging. Here, we present a summary of the recently introduced optical sieve, a photonic sensing platform based on resonant void arrays embedded within a high-refractive-index medium. These air-filled voids enable strong light confinement and simultaneously serve as passive sorting elements and intrinsic color reporters. When individual nanoplastic particles interact with the voids, they induce distinct spectral shifts that become observable as color changes under a standard optical microscope equipped with an RGB camera. By tailoring the diameter and depth of the voids, the platform enables the detection, sizing, and counting of individual nanoplastic particles. The detected colors of empty and particle-filled voids can be mapped within defined color spaces. However, when refractive index contrasts become small, the corresponding color clusters converge and may overlap, complicating reliable classification. To overcome this limitation, advanced data analysis techniques such as principal component analysis can be employed to enhance separability. Here, we demonstrate a novel integration of photonic nanoplastic detection and counting with advanced clustering approaches, improving detection fidelity.

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