Resveratrol counteracts redox imbalance and mitochondrial dysfunctions induced by nano and microplastics (NMPs) in human granulosa cells

Environmental Microplastics, Mitochondrial Health and Human Diseases

AI summary · Read the abstract

Researchers investigated how environmental microplastics disrupt mitochondrial function, linking plastic particle exposure to oxidative stress, impaired energy metabolism, and inflammatory pathways that may contribute to a range of human diseases.

Microplastics and nanoplastics in human health: a comprehensive review of exposure pathways, cellular mechanisms, and toxicological implications

AI summary · Read the abstract

Researchers reviewed human exposure pathways to microplastics and nanoplastics through seafood, salt, drinking water, inhalation, and skin contact, examining how these particles cross biological barriers to reach organs and trigger oxidative stress, inflammation, and endocrine disruption with poorly understood long-term consequences.

Composite polyphenols mitigate microplastic exposure-related immune disturbances: a two-phase population trial

AI summary · Read the abstract

Researchers conducted a randomized, double-blind, placebo-controlled trial (n=98) showing that a composite polyphenol supplement significantly reduced pro-inflammatory cytokines IL-1β, IL-6, and IL-8 in participants with high fecal microplastic loads by modulating gut microbiota and glycerophospholipid metabolism.

Avaliação do efeito de citotoxicidade dos microplásticos na linhagem mamária humana MCF10A

AI summary · Read the abstract

Researchers assessed the cytotoxicity of microplastics on the non-tumoral human breast cell line MCF10A and explored whether the antioxidant resveratrol could mitigate those effects. The study found that microplastics negatively impacted cell viability and that resveratrol showed potential as a protective agent in the cellular context of MP exposure.

Molecular mechanisms of microplastics toxicity