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Machine Learning‐Driven Prediction of Microplastic Aging Processes and Environmental Risk Assessment Across Multi‐Media Systems

Original title: Machine Learning‐Driven Prediction of Microplastic Aging Processes and Environmental Risk Assessment Across Multi‐Media Systems

Advanced Science 2026
Yaping Lyu, Xinran Qiu, Li X, Tianhuan Yang, Xuetao Guo, Hao Qiu, Peng Zhang

Summary

Scientists are proposing a new AI-powered strategy to better predict how microplastics break down and change as they travel through air, water, and soil—and how that affects their toxicity to living things. Rather than presenting new findings, this paper is a roadmap for combining smarter computer models with secure data-sharing between institutions to close the gap between lab tests and what actually happens to plastic pollution in the real world. This matters because understanding how microplastics age and interact with biological systems is a key step toward assessing their risks to human health and the environment.

Machine learning (ML) holds promise for reconstructing microplastic (MP) aging and assessing risks, but current studies rely on small-scale, accelerated laboratory datasets and single environmental medium models that miss cross-media transport and environmental interactions in real-world MP lifecycles. To realize its potential for reconstructing spatiotemporal aging trajectories and toxicological assessment of MPs, this perspective provides a paradigm shift in ML application from fragmented data-fitting to a holistic, privacy-preserving, physics-aware strategy. A novel probabilistic framework reconstructs the environmental history of field-sampled MPs through mechanistic fingerprinting, using Bayesian inference to reconcile multi-evidence signals and improve trajectory models for source attribution and risk assessment. Furthermore, we propose the TRACE framework (TRansport, Aging, Corona, Ecotoxicity), which moves beyond the isolated modeling of aging processes and toxicity endpoints. By integrating physics-informed models with causal discovery, TRACE captures the reciprocal feedback loops between physicochemical evolution and eco-corona formation, thereby mechanistically linking surface transformations to biological risks. To support this data-intensive architecture, we advocate for federated learning (FL) to dismantle privacy barriers. This approach facilitates secure, multi-institutional collaborative modeling without raw data exchange, harmonizing heterogeneous datasets. Ultimately, this cohesive strategy bridges laboratory-field disparities, moving toward predictive, evidence-based, and targeted mitigation efforts in global plastic pollution governance.

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