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Microbial Degradation of Plastics: Mechanisms, Pathways, and Multiomics Insights
Summary
Scientists are exploring how to use bacteria and other microbes to break down plastic waste, since plastic pollution can pose risks to ecosystems and human health. This review pulls together existing research on how these microbes work and points out that results vary so much between studies that it's hard to tell which methods might actually work in the real world. The takeaway: microbial plastic cleanup is a promising idea, but it needs more consistent testing before it can move from the lab to actually reducing plastic pollution (and the microplastics we're exposed to) at scale.
Plastic pollution is a major environmental challenge, given its widespread presence and potential risks to both ecosystems and human health. Microbial biodegradation offers a promising solution for managing plastic waste. However, research in this area remains fragmented, with varying reports on degradation efficiency, mechanisms, and practical applications. This review synthesizes recent developments in microbial taxonomy, enzymatic depolymerization, and multiomics functional analysis, highlighting the connections between microbial traits and the four key stages of plastic degradation: colonization, depolymerization, assimilation, and mineralization. It critically evaluates the robustness and comparability of reported degradation metrics, demonstrating that variability in polymer properties, experimental conditions and assessment methods severely hinders meaningful comparisons across studies and limits the translation of laboratory findings to real-world applications. Additionally, this review elaborates on emerging bioaugmentation strategies such as genetic modification, enzyme engineering and synthetic microbial consortia design, while identifying key translational bottlenecks involving scalability, environmental relevance and long-term stability. By integrating insights from multiomics research and synthetic biology, this work proposes a framework to bridge the gap between laboratory-based discoveries and practical biodegradation strategies. It aims to advance microbial plastic remediation research by identifying key knowledge gaps and offering actionable recommendations for future developments.