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Supplementary Tables S1-S38 from Association of Blood Levels of Forever Plastics with Lung Cancer Mortality among Ever Smokers in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cohort Study
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Researchers looked at "forever chemicals" (PFAS) and plastic-related chemicals in the blood of longtime smokers and found that higher levels of these substances were linked to a greater risk of dying from lung cancer, even after accounting for smoking habits. This suggests that everyday exposure to these persistent chemicals—found in things like nonstick cookware, food packaging, and water-resistant products—may add to cancer risk on top of smoking, making it another reason to reduce contact with these chemicals when possible.
Supplementary Table 1. Detectable microplastics (MP), per- and polyfluoroalkyl substances (PFAS), and plasticizers (BPA and phthalates) in the internal mass spectrometry database. Supplemental Table S2. Patient characteristics for the Development and Validation Set. Supplementary Table S3. Association between detected PFAS and plasticizers with lung cancer incidence when adjusting for age and smoking as confounding variables. Supplementary Table S4. Association between detected PFAS and plasticizers with lung cancer incidence in the entire PLCO dataset when stratifying samples into quantiles. Supplementary Table S5. Association between detected PFAS and plasticizers with lung cancer incidence stratifying by sex in the entire PLCO dataset. Supplementary Table S6. Association between detected PFAS and plasticizers with lung cancer incidence stratifying by age in the entire PLCO dataset. Supplementary Table S7. Association between detected PFAS and plasticizers with lung cancer incidence stratifying by smoking intensity in the entire PLCO dataset. Supplementary Table S8. Association between detected PFAS and plasticizers with lung cancer incidence stratifying by ethnicity in the entire PLCO dataset. Supplementary Table S9. Association between detected PFAS and plasticizers with lung cancer incidence in the entire PLCO specimen set when stratifying by stage at diagnosis. Supplementary Table S10. Association between detected PFAS and plasticizers with lung cancer incidence in the entire PLCO specimen set when stratifying by lung cancer subtype at the time of clinical diagnosis. Supplementary Table S11: Causes of death for the participants in the PLCO cohort. Supplementary Table S12. Association between detected PFAS and plasticizers with lung cancer mortality in the entire PLCO dataset using cause-specific hazard ratios. Supplementary Table 13. Association between detected PFAS and plasticizers with lung cancer mortality using cause-specific hazard ratio in the entire PLCO dataset when adjusting for age and smoking intensity. Supplementary Table S14. Association between detected PFAS and plasticizers with lung cancer mortality in the entire PLCO dataset using cause-specific hazard ratios stratifying by sex. Supplementary Table S15. Association between detected PFAS and plasticizers with lung cancer mortality in the entire PLCO dataset using cause-specific hazard ratios stratifying by age. Supplementary Table S16. Association between detected PFAS and plasticizers with lung cancer mortality in the entire PLCO dataset using cause-specific hazard ratios stratifying by smoking intensity. Supplementary Table S17. Association between detected PFAS and plasticizers with lung cancer mortality in the entire PLCO dataset using cause-specific hazard ratios stratifying by ethnicity. Supplementary Table S18. Association between detected PFAS and plasticizers with lung cancer mortality in the entire PLCO dataset using cause-specific hazard ratios stratifying by stage at diagnosis. Supplementary Table S19. Association between detected PFAS and plasticizers with lung cancer mortality in the entire PLCO dataset using cause-specific hazard ratios stratifying by lung cancer subtype at the time of clinical diagnosis. Supplementary Table S20. Association between detected PFAS and plasticizers with lung cancer mortality in the entire PLCO dataset using sub-distributional hazard ratio. Supplementary Table 21. Association between detected PFAS and plasticizers with lung cancer mortality using sub-distributional hazard ratio in the entire PLCO dataset when adjusting for age and smoking intensity. Supplementary Table S22. Association between detected PFAS and plasticizers with lung cancer mortality in the entire PLCO dataset using sub-distributional hazard ratio stratifying by sex. Supplementary Table S23. Association between detected PFAS and plasticizers with lung cancer mortality in the entire PLCO dataset using sub-distributional hazard ratio stratifying by age. Supplementary Table S24. Association between detected PFAS and plasticizers with lung cancer mortality in the entire PLCO dataset using sub-distributional hazard ratio stratifying by smoking intensity. Supplementary Table S25. Association between detected and plasticizers with lung cancer mortality in the entire PLCO dataset using sub-distributional hazard ratio stratifying by ethnicity. Supplementary Table S26. Association between detected PFAS and plasticizers with lung cancer mortality in the entire PLCO dataset using sub-distributional hazard ratio stratifying by stage at diagnosis. Supplementary Table S27. Association between detected PFAS and plasticizers with lung cancer mortality in the entire PLCO dataset using sub-distributional hazard ratio stratifying by lung cancer subtype at the time of clinical diagnosis. Supplementary Table S28. Association between the PFAP model with lung cancer mortality using cause-specific and sub-distributional hazard ratio in the PLCO Development and Testing sets. Supplementary Table S29. Variance inflation factors for features included in the PFAP model. Supplementary Table S30. Likelihood ratio test P values comparing linear and cubic spline Cox models for associations with survival. Supplementary Table S31. Continuous hazard ratios for lung cancer–specific mortality using a cause-specific approach for PFAP under different sampling approach. Supplementary Table S32. Association between the PFAP model with lung-cancer mortality using cause-specific and sub-distributional hazard ratio in the entire PLCO dataset when adjusting for age, sex, BMI, smoking status, education, and emphysema. Supplementary Table S33. Association between the PFAP model with lung-cancer mortality using cause-specific and sub-distributional hazard ratio in the entire PLCO dataset when excluding deaths within 1-, 2-, and 5-years after sample collection. Supplementary Table S34. Performance estimates (AUC and C-index) of the PFAP model for lung cancer–specific mortality at 5-, 10-, and 15-years following blood collection. Supplementary Table S35. Association between the PFAP model with all-cause mortality in the entire PLCO dataset using Cox models. Supplementary Table S36. Association between the PFAP model with other-cause mortality using cause-specific and sub-distributional hazard ratio in the entire PLCO dataset. Supplementary Table S37. Association between the PFAP model with other-cause cancer mortality using cause-specific and sub-distributional hazard ratio in the entire PLCO dataset. Supplementary Table S38. Association between the PFAP model with other-cause non-cancer mortality using cause-specific and sub-distributional hazard ratio in the entire PLCO dataset.
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