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Micro- and nanoplastics as potential neuroendocrine disruptors: data and analysis files
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This project shares the planning documents and data files behind a research review examining whether tiny plastic particles (microplastics and even smaller nanoplastics) might interfere with the body's hormone and brain-signaling systems. Since this is a behind-the-scenes methods resource rather than a study with results, it doesn't yet tell us whether plastics actually harm our hormones—but it lays the groundwork for a rigorous analysis that could help answer that question. Keep an eye out for the completed review, which will pull together existing studies to see if there's real evidence linking plastic exposure to hormone-related health effects.
This OSF project contains the a priori analytical plan, PECO framework, search strategies, effect-level extraction dataset, and R scripts for the systematic review and subgroup meta-analysis on micro- and nanoplastics as potential neuroendocrine disruptors.
More Papers Like This
Endocrine Toxicity of Micro- and Nanoplastics, and Advances in Detection Techniques for Human Tissues: A Comprehensive Review
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This review summarizes growing evidence that micro- and nanoplastics contain or carry endocrine-disrupting chemicals that interfere with hormones throughout the body, triggering oxidative stress, inflammation, and cell death in hormone-producing tissues. The paper also reviews new detection methods that can identify and measure these tiny plastic particles in human blood, tissue, and other biological samples, which is essential for understanding real-world health impacts.
Neuroactive steroids as targets of micro- and nano-plastics: Putative impact on brain function and disease
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This review paper looks at how tiny plastic particles (microplastics and nanoplastics) that build up in our bodies may disrupt hormones that our brain cells make and use to function properly—hormones that affect mood, brain cell growth, and overall mental health. While scientists already know these plastics can mess with reproductive hormones, this paper highlights that we still don't fully understand their effects on brain-specific hormones, suggesting this is an important but understudied area for protecting mental health as plastic pollution continues to grow.
Microplastics as Emerging Contaminants: Investigating their Potential to Alter Human Metabolic and Endocrine Systems
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This review investigated the potential of microplastics to alter human hormone signaling, synthesizing evidence that plastic particles and their chemical additives can act as endocrine disruptors at environmentally relevant concentrations. The paper highlighted reproductive and metabolic pathways as areas of particular concern.
The Impact of Microplastics and Nanoplastics on Human Health: A Follow-Up Study Focusing on Endocrine, Nervous, and Immune Systems
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This review examines evidence for microplastic and nanoplastic impacts on the endocrine, nervous, and immune systems, documenting how particles detected in human organs can disrupt hormone signaling, induce neuroinflammation, and alter immune function.
Nano and microplastics: unveiling their profound impact on endocrine health
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This review summarizes existing research showing that micro- and nanoplastics can disrupt the endocrine (hormone) system, altering reproductive hormones, thyroid function, and gene expression in lab and animal studies. Exposure to these particles triggered inflammation markers and oxidative stress in hormone-producing organs, suggesting that widespread plastic pollution may be contributing to rising rates of hormonal and reproductive health problems.
Research digests by email
When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.