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Toxicity of microplastics and associated chemicals: A comprehensive review of the current state of knowledge
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Researchers synthesize current evidence on microplastic toxicity, finding that MPs and their co-contaminants — including plasticizers, flame retardants, and heavy metals — induce oxidative stress, inflammation, endocrine disruption, and microbiome changes across organisms, while noting that inconsistent methods and limited chronic-exposure data remain key barriers to accurate human risk assessment.
Microplastics (MPs) have rapidly emerged as a global environmental and public health concern, infiltrating ecosystems ranging from the deepest oceans to the most remote terrestrial and atmospheric regions. Their small size, chemical complexity, and remarkable persistence enable them to interact intimately with biological systems, creating a multifaceted toxicological challenge. In addition to the inherent properties of polymer particles, MPs serve as carriers for a diverse array of chemical additives and environmental contaminants including plasticizers, flame retardants, pesticides, metals, and persistent organic pollutants, amplifying their potential toxicity. As a result, MPs can induce oxidative stress, inflammation, endocrine disruption, metabolic disorders, and microbiome alterations across a wide range of organisms, with growing evidence suggesting implications for human health through ingestion, inhalation, and trophic transfer. Despite the escalating body of research, critical uncertainties persist. Variability in particle characteristics, inconsistent analytical methods, and limited understanding of chronic and low-dose exposures continue to hinder accurate risk assessment. Moreover, the increasing detection of nanoplastics raises additional concerns due to their enhanced reactivity and capacity to cross biological barriers. This review synthesizes current knowledge on the toxicity of microplastics and associated chemicals, integrating findings from environmental distribution, mechanistic toxicology, ecotoxicological effects, and human health implications. Key methodological challenges are highlighted, alongside emerging tools and policy efforts aimed at mitigating risks. By providing a comprehensive and forward-looking analysis, this review underscores the urgent need for standardized monitoring, interdisciplinary research, and regulatory action to address one of the most pervasive contaminants of the modern era.
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This comprehensive review synthesizes current understanding of how micro- and nanoplastics cause biochemical toxicity across biological systems, from plants and invertebrates to vertebrates and humans. Key mechanisms include oxidative stress, membrane disruption, immune activation, genotoxicity, endocrine disruption, and microbiome perturbation, all modulated by particle size, shape, and surface chemistry. The authors highlight critical gaps in standardization, chronic low-dose effect data, and the need for translatable biomarkers for risk assessment.
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This review summarizes how microplastics cause toxic effects across water, soil, and air ecosystems by triggering oxidative stress, inflammation, and disrupting metabolic pathways in exposed organisms. The research highlights that while we know microplastics cause harm at the cellular level, there are still major gaps in understanding exactly how much exposure is dangerous for human health.
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