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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Policy & Risk Reproductive & Development Sign in to save

Feedback Regulation of sPLA2-COX/5-LOX-Ca2+ in Seminal Plasma and Its Impact on Sperm Quality Parameters

Journal of Inflammation Research 2025 Score: 38 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Yongjie Liu, Liang Dai, Fan Zhang, Yang Liu, Li Xu, Guoping Wang

Summary

Researchers investigated feedback regulation of the sPLA2-COX/5-LOX-Ca2+ pathway in seminal plasma and its impact on sperm quality parameters. The study found that arachidonic acid metabolism in seminal plasma strongly influences sperm quality, with the PL-AA-COX1 model proposed as a sperm quality predictor and AA/COX1 supplementation shown to protect sperm under heat stress.

Body Systems
Reproductive

Seminal plasma AA metabolism strongly influences sperm quality, likely via sPLA2-COX/5-LOX-Ca²<sup>+</sup> feedback mechanisms. The PL-AA-COX1 model may serve as a sperm quality predictor, and AA/COX1 supplementation could protect sperm under heat stress.

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