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Impact of Nanoplastic Particles on Intestinal Epithelium Health Using a Vascularized Gut-on-aChip Model
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Researchers developed a vascularized gut-on-a-chip model to assess how nanoplastic particles affect the intestinal barrier, focusing on bioaccumulation, translocation across epithelial and endothelial layers, and disruption of mucus and immune interfaces under physiologically relevant conditions.
Nanoplastics (NPLs), small plastic particles formed from the environmental breakdown of larger plastics, are known bioavailable contaminants. Their size enables them to cross biological barriers, interact with epithelial and immune cells, and transport toxic additives and biofilm-forming microbes. These properties highlight the urgent need to understand their effects on human health, particularly in the gastrointestinal tract (GI), a primary site of exposure through ingestion. Despite mounting evidence linking NPLs to health issues like immune response and inflammation, their impact on gut health using physiologically relevant models remains poorly characterised. The objective of the project is to develop a novel proof-of-principle gut-on-chip model to evaluate the impact and toxicity of NPLs on gut health, focusing on bioaccumulation, translocation, and barrier integrity at the endothelium, epithelium, mucus and immune interface.
More Papers Like This
Impact of Nanoplastic Particles on Intestinal Epithelium Health Using a Vascularized Gut-on-aChip Model
AI summary Read the abstract
Researchers developed a vascularized gut-on-a-chip model to evaluate how nanoplastics affect intestinal health, focusing on bioaccumulation, translocation across epithelial barriers, and immune responses at the gut-blood interface — a more physiologically realistic platform than conventional cell culture approaches.
Impact of Nanoplastic Particles on Intestinal Epithelium Health Using a Vascularized Gut-on-aChip Model
AI summary Read the abstract
Researchers developed a vascularized gut-on-a-chip model to evaluate how nanoplastics affect intestinal health, focusing on bioaccumulation, translocation across epithelial barriers, and immune responses at the gut-blood interface — a more physiologically realistic platform than conventional cell culture approaches.
Impact of Nanoplastic Particles on Intestinal Epithelium Health Using a Vascularized Gut-on-aChip Model
AI summary Read the abstract
Researchers developed a vascularized gut-on-a-chip model to evaluate how nanoplastics affect intestinal health, focusing on bioaccumulation, translocation across epithelial barriers, and immune responses at the gut-blood interface — a more physiologically realistic platform than conventional cell culture approaches.
Nanoplastic Impact on Human Health—A 3D Intestinal Model to Study the Interaction with Nanoplastic Particles
AI summary Read the abstract
Researchers used a three-dimensional intestinal model to study how nanoplastic particles interact with human gut tissue, finding that nanoplastics can cross the intestinal epithelial barrier and induce inflammatory responses, providing more physiologically relevant evidence than prior two-dimensional cell culture studies of nanoplastic health risks.
A human Caco-2-based co-culture model of the inflamed intestinal mucosa for particle toxicity studies
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Researchers developed an advanced intestinal co-culture model using human Caco-2 cells to better study the toxicity of particles, including micro- and nanoplastics, on inflamed intestinal tissue. The model incorporates immune cells to simulate intestinal inflammation, providing a more physiologically relevant in vitro system for evaluating how plastic particles interact with the gut barrier under both healthy and inflamed conditions.
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