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Oral Exposure to Polypropylene Microplastics Exacerbates Cow’s Milk Allergy in a Murine Model by Skewing the DCs/T-Cell Response toward Th2 Polarization
Summary
Researchers demonstrated using a dendritic cell and T-cell co-culture system that polypropylene microplastic exposure enhances antigen uptake and skews T-cell differentiation toward the Th2 immune response, potentially worsening cow's milk allergy susceptibility in infants — highlighting food contamination with microplastics as a plausible driver of rising allergy prevalence.
DCs/T-cell coculture system confirmed that PP enhanced antigen uptake by DCs and shifted naïve T-cell differentiation toward Th2 polarization, eventually aggravating CMA susceptibility. This study highlighted the potential health risk posed by NMPs contamination in food and suggested a possible contribution to the escalating prevalence of CMA in infants.