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Plastic-degrading clusters of orthologous groups reveal near-universal biodegradation potential in prokaryotes
Summary
Bioinformatic analysis of prokaryotic genomes identified a set of Plastic-Degrading Clusters of Orthologous Groups, revealing that plastic-degrading protein families are distributed across diverse bacterial and archaeal lineages, suggesting near-universal biodegradation potential in microbial communities.
ABSTRACT Micro- and nanoplastic pollution (MNPP) is an increasing environmental threat due to the persistence, dispersal, and potential toxicity of plastic particles. Although microbial biodegradation offers a sustainable mitigation strategy, a comprehensive understanding of plastic-degrading proteins across microbial taxa is lacking. Here, we present the Plastic-Degrading Clusters of Orthologous Groups (PDCOGs) database ( https://phylobone.com/microworld/PDCOG ), comprising 625,616 potential plastic-degrading proteins (PPDPs) from free-living prokaryotes organized into 51 orthologous groups. The database/PDCOGs enable systematic analysis of microbial plastic-degrading capacity across ecosystems and phylogenetic lineages. Notably, PPDPs constitute ∼3.5% of all prokaryotic proteins, with over 95% of the species having the potential to biodegrade at least one plastic polymer type. This resource provides a genomic tool/framework for exploring the ecological and evolutionary importance of plastic biodegradation and supports future efforts to mitigate the global MNPP crisis.