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Prenatal DEHP exposure induces lifelong testicular toxicity by continuously interfering with steroidogenic gene expression
Summary
Researchers found that prenatal exposure to DEHP, a common plasticizer, causes lasting testicular toxicity in males by persistently disrupting the expression of genes involved in steroid hormone production, suggesting a mechanistic link between early-life phthalate exposure and adult male reproductive disorders including potential accelerated reproductive aging.
Prenatal DEHP exposure induces lifelong testicular toxicity by continuously interfering with steroidogenic gene expression, thus indicating the association between prenatal exposure and DSD, adult male disorders, and reproductive aging.