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Disruptive effects of plasticizers bisphenol A, F, and S on steroidogenesis of adrenocortical cells

Environmental Technology & Innovation 2024 7 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Benedikt Pötzl, Lydia Kürzinger, Sabine Kendl, Helga Stopper, Max Kurlbaum, Martin Faßnacht, Ulrich Dischinger

Summary

This study found that bisphenol A, F, and S all disrupt steroidogenesis in adrenocortical cells at non-cytotoxic concentrations in cell culture, producing compound-specific alterations in hormone levels, providing evidence that BPF and BPS are not necessarily safer endocrine alternatives to BPA.

Body Systems
Endocrine
Study Type In vivo

In cell culture, bisphenols interfere with steroidogenesis at non-cytotoxic levels, leading to compound-specific patterns of significantly altered hormone levels. These results justify and call for additional in-vivo studies to evaluate effects of EDCs on adrenal gland functionality.

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