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Disruptive effects of plasticizers bisphenol A, F, and S on steroidogenesis of adrenocortical cells
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This study found that bisphenol A, F, and S all disrupt steroidogenesis in adrenocortical cells at non-cytotoxic concentrations in cell culture, producing compound-specific alterations in hormone levels, providing evidence that BPF and BPS are not necessarily safer endocrine alternatives to BPA.
In cell culture, bisphenols interfere with steroidogenesis at non-cytotoxic levels, leading to compound-specific patterns of significantly altered hormone levels. These results justify and call for additional in-vivo studies to evaluate effects of EDCs on adrenal gland functionality.
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Effects of Endocrine-Disrupting Chemicals on Adrenal Function
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This review examines how endocrine-disrupting chemicals, including microplastics, affect the adrenal glands, which produce hormones that regulate metabolism, blood pressure, and stress response. Evidence shows these chemicals can damage adrenal gland structure and disrupt hormone production, with some effects even passing to future generations. The authors argue that adrenal glands have been overlooked in safety testing and need to be included in screening for harmful chemicals.
Hormônios Esteroides E a Influência Do Bisfenol-a
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This review examines the impact of bisphenol-A (BPA), a substance found in plastics, on steroid hormone metabolism based on articles from Scielo and PubMed published between 2016 and 2023. The review finds that BPA disrupts estrogen receptor signaling across reproductive and nervous system tissues through estrogenic and oxidative/pro-apoptotic mechanisms, and that despite its short half-life, continuous exposure leads to accumulation detectable in blood and urine.
Detrimental consequences of micropolymers associated plasticizers on endocrinal disruption
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This review details how microplastics, nanoplastics, and plastic-associated plasticizers act as endocrine-disrupting chemicals, interfering with signaling pathways in the pituitary, thyroid, adrenal, and gonadal glands in ways that disrupt hormones, metabolism, fertility, neural development, and fetal growth.
Polystyrene microplastics disrupt adrenal steroid synthesis in male mice via mitochondrial dysfunction
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Researchers found that polystyrene microplastics disrupted steroid hormone production in the adrenal glands of male mice by causing mitochondrial dysfunction and oxidative stress. Chronic exposure led to reduced corticosterone levels and increased cell death in adrenal tissue. The study suggests that microplastics may interfere with the body's stress response and hormonal balance through damage to the energy-producing structures within cells.
The effect of plastic substances on the pituitary gland
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This review examined the effects of plastic-derived chemical substances, including plasticizers and BPA, on pituitary gland function, summarizing evidence that endocrine-disrupting compounds alter hormone secretion and pituitary cell biology.
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When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.