We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Evaluation of the Effects of Di-(2-ethylhexyl) phthalate (DEHP) on Caenorhabditis elegans Survival and Fertility
Summary
Researchers exposed the model organism C. elegans to di-(2-ethylhexyl) phthalate (DEHP) and found it significantly shortened lifespan and reduced fertility by up to 30%, with a lethal concentration (LC50) of 321 µg/mL, underscoring DEHP's toxicity as a widespread environmental contaminant.
Di-2-ethylhexyl (DEHP), which is widely used in industrial products, is produced annually in excess of 2 million tons worldwide. DEHP is an endocrine disruptor and one of the major environmental pollutant chemicals (EDCs) in nature. There is some information about the effects of these products, which provide great advantages in every respect, on human health and the environment. In this study, C. elegans organism was used to evaluate the health and environmental risks of DEHP. The survival and fertility effects of DEHP on the C. elegans organism were examined and the results were evaluated. In the study, it was determined that DEHP not only shortened the survival time of C. elegans but also caused a decrease in fertility. DEHP (0.625 mM and 10 mM) caused a 23.2-30.6% decrease in fertility. Additionally, the LC50 (50% lethal concentration) value of DEHP was found to be 321 µg/mL.