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Impact of Bisphenol A and its alternatives on oocyte health: a scoping review
Summary
This scoping review examines evidence that low-level exposure to bisphenol A (BPA) and its chemical alternatives impairs oocyte quality and reduces fertility, highlighting serious reproductive toxicity concerns with these endocrine-disrupting chemicals. The authors call for updated international policy guidelines and stronger study design standards to better protect reproductive health.
These data highlight the detrimental impacts of low-level BPA and BPA alternative exposure, contributing to poor oocyte quality and reduced fertility. These outcomes are valuable in promoting the revision of current policies and guidelines pertaining to BPA exposure internationally. This study serves as a valuable resource to scientists, providing key recommendations on study design, reporting elements, and endpoint measures to strengthen future studies. Ultimately, this review highlights oocyte health as a fundamentally important endpoint in reproductive toxicological studies, indicating an important direction for future research into endocrine disrupting chemicals to improve fertility outcomes.